What is KPV 10MG?

KPV is a synthetic tripeptide composed of the amino acids Lysine–Proline–Valine (Lys–Pro–Val). It represents the C-terminal sequence (amino acids 11–13) of α-melanocyte-stimulating hormone (α-MSH) and is widely studied as a minimal active fragment with anti-inflammatory activity in preclinical research.

Chemical Structure of KPV 10MG

Sequence: Lys–Pro–Val (KPV)

Molecular formula: C₁₆H₃₀N₄O₄

Approx. molecular weight: 342.43 g/mol

PubChem CID / identifiers: CID 125672 (listed under MSH (11–13) / Lys–Pro–Val)

Synonyms: α-MSH(11–13), ACTH(11–13), MSH(11–13)
These chemical identifiers and basic physicochemical data are recorded in chemical databases and supplier specifications.

What Are the Effects of KPV 10MG?

Anti-inflammatory activity (gut and systemic models) — KPV reduces pro-inflammatory cytokine expression (examples: IL-1β, IL-6, TNF-α) and attenuates experimental colitis and other inflammation models. Its effect in the gut is at least partly explained by transporter-mediated uptake (PepT1), which delivers the tripeptide into epithelial and immune cells where it modulates intracellular inflammatory signaling.

Mucosal healing & tissue repair — KPV has been shown to improve epithelial integrity and accelerate mucosal recovery in gastrointestinal injury models, reducing inflammatory infiltrates and improving histological outcomes.

Mechanism notes — KPV’s actions appear to be largely independent of classical melanocortin receptor activation (i.e., effects are retained even without MC1R signaling) and involve intracellular pathways following PepT1 uptake; the precise intracellular targets are still under study.

Additional findings & translational research — Emerging work explores KPV’s use in targeted delivery systems (nanoparticles, hydrogels) for improving local anti-inflammatory and antimicrobial effects (e.g., wound / mucosal applications). While preclinical data are promising, evidence from human clinical trials is limited.

Product & Quality Notes (research supply)

Form & purity (typical supplier specs): white lyophilized powder, ≥98.5% purity by HPLC (supplier specs vary — check COA).

Storage: store frozen or refrigerated per supplier guidance (commonly −20 °C), protect from moisture and light.

Intended use: Research use only — not for human or veterinary administration.

Legal Disclaimer & Safety Information

This compound is sold for research purposes only. It is not approved for human consumption, therapeutic use, or as a dietary supplement. Handle only in an appropriate laboratory setting by qualified personnel. Keep out of reach of children. Misuse may result in unknown adverse outcomes.

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