What is 5-Amino-1MQ Capsules 50mg 60 cap?

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small-molecule research compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme central to nicotinamide and NAD⁺ metabolic pathways. By blocking NNMT activity, 5-Amino-1MQ preserves nicotinamide for NAD⁺ synthesis, which is a key cofactor in cellular energy production, redox reactions, and regulation of metabolic signaling cascades in preclinical and in-vitro studies.

NNMT is highly expressed in adipose tissue and is associated with metabolic dysregulation, increased fat storage, and lower cellular energy availability. In research settings, inhibition of NNMT is explored for its effects on metabolic regulation, NAD⁺ homeostasis, mitochondrial function, and related pathways.

Each capsule contains 50 mg of 5-Amino-1MQ.

Chemical Structure of 5-Amino-1MQ Capsules 50mg 60 cap

Chemical Name: 5-amino-1-methylquinolinium (cation)

Core Structure: Quinolinium base with a 5-amino substituent and N-methyl group

Molecular Formula: C₁₀H₁₁N₂⁺ (quinolinium cation)

Molecular Weight: ~159.21 g/mol (cation)

CAS Identifiers: Listed in multiple chemical registries for research use (e.g., CAS 42464-96-0 for 5-amino-1-methylquinolinium)

The quinolinium structure enables 5-Amino-1MQ to penetrate cells and interact with the NNMT enzyme in the cytosol, influencing nicotinamide methylation and downstream metabolic pathways.

What Are the Effects of 5-Amino-1MQ Capsules 50mg 60 cap?

(Preclinical & Laboratory Research Only)

• NNMT Inhibition & NAD⁺ Preservation
5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), preventing conversion of nicotinamide into 1-methylnicotinamide (1-MNA). This promotes retention of nicotinamide for NAD⁺ biosynthesis, which is crucial for enzymes involved in cellular energy and redox balance.

• Enhanced Cellular Energy & Metabolic Activity
By increasing cellular NAD⁺ availability, research models show improvements in mitochondrial function, oxidative metabolism, and overall metabolic signaling. These changes were linked to increased energy throughput and modulation of metabolic pathways in preclinical studies.

• Metabolic Regulation & Fat Metabolism Research
In animal research, NNMT inhibition by 5-Amino-1MQ has been associated with increased energy expenditure, reduced fat accumulation, and improved metabolic indicators without reducing food intake. These findings make it useful for studies of adipocyte biology, energy balance, and lipid metabolism.

• Insulin Sensitivity & Glucose Pathways
Some research has linked NNMT inhibition with improved insulin sensitivity and enhanced glucose handling in preclinical models, consistent with enhanced metabolic efficiency mediated by NAD⁺-dependent pathways.

• Cellular Signaling & Epigenetic Effects
5-Amino-1MQ also influences cellular methyl donors by altering S-adenosyl-methionine (SAM) and related pathways. Preservation of SAM can impact molecular signaling and epigenetic regulation in cell culture and animal models.