What is HCG 10000iu?

Human Chorionic Gonadotropin (HCG) is a naturally occurring placental glycoprotein hormone that binds to and activates the luteinizing hormone/choriogonadotropin receptor (LHCGR). It is structurally similar to luteinizing hormone (LH), but contains unique features that prolong its half-life and biochemical activity.

In research environments, HCG is widely used to study:

Luteinizing hormone receptor signaling

Reproductive endocrinology

Steroidogenesis

Paracrine communication

Angiogenesis and cellular development

This product is intended for laboratory and scientific research use only.

Chemical Structure of HCG 10000iu

HCG is a heterodimeric glycoprotein hormone, approximately 37.9 kDa, composed of two subunits:

• Alpha (α) Subunit – 92 amino acids

Shared with LH, FSH, and TSH.
Contains two N-linked glycosylation sites.

• Beta (β) Subunit – 145 amino acids

Unique to HCG.
Includes an extended C-terminal peptide (CTP) of 24 amino acids, responsible for increasing its half-life.
Contains two N-linked and four O-linked glycosylation sites.

Key Structural Features

~30% carbohydrate content — improves stability and biological persistence

Eight total sugar chains

Cystine-knot motif with three disulfide bonds per subunit, providing structural rigidity essential for receptor binding

This complex structural arrangement gives HCG high receptor affinity and long-lasting signaling capability.

What Are the Effects of HCG 10000iu?

Preclinical and in-vitro research demonstrates that HCG participates in several biological pathways:

• LHCGR-Mediated Signaling

Activates Gs and Gq protein pathways

Stimulates cAMP production

Promotes steroidogenesis in gonadotrophin-responsive cells

• Angiogenic & Paracrine Activity

Induces endothelial cells to release VEGF and other angiogenic factors

Supports tissue vascularization in experimental models

• Reproductive Endocrine Modulation

Enhances progesterone secretion

Supports oocyte maturation

Aids in early embryonic development (in research contexts)

• Biased Agonism

HCG produces unique signaling kinetics compared to LH:

More sustained cAMP responses

Distinct gene-expression patterns

Longer duration of receptor activation

These characteristics make HCG a valuable tool for studying differential LHCGR signaling.

Research-Use Disclaimer

HCG 10,000 IU is supplied strictly for laboratory, educational, and scientific research purposes.
It is not intended for human or veterinary administration.